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Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.

Am J Geriatr Psychiatry. 2015; 
Whitfield David R,Vallortigara Julie,Alghamdi Amani,Hortobágyi Tibor,Ballard Clive,Thomas Alan J,O'Brien John T,Aarsland Dag,Francis Pa
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摘要

Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in depression and synaptic dysfunction. We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study.

关键词

Alzheimer disease,Depression,Lewy body dementia,Parkinson disease dementia,